Mouse Aass activation kit by CRISPRa

CAT#: GA205307

Aass CRISPRa kit - CRISPR gene activation of mouse aminoadipate-semialdehyde synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aass
• Locus ID: 30956
• Kit Components:

  GA205307G1, Aass gRNA vector 1 in pCas-Guide-CRISPRa

  GA205307G2, Aass gRNA vector 2 in pCas-Guide-CRISPRa

  GA205307G3, Aass gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013930
• Synonyms: LKR; LKR/SDH; LOR; LOR/SDH; Lorsdh; SDH
• Summary: This gene encodes a bifunctional mitochondrial protein that catalyzes the first two steps in the lysine degradation pathway. The N-terminus contains lysine-ketoglutarate reductase activity and converts lysine to saccharopine, whereas the C-terminus contains saccharopine dehydrogenase activity and converts saccharopine to alpha-aminoadipate semialdehyde. Mutations in a human gene encoding a highly similar protein are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]