Mouse Ccdc22 activation kit by CRISPRa

CAT#: GA205748

Ccdc22 CRISPRa kit - CRISPR gene activation of mouse coiled-coil domain containing 22

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ccdc22
• Locus ID: 54638
• Kit Components:

  GA205748G1, Ccdc22 gRNA vector 1 in pCas-Guide-CRISPRa

  GA205748G2, Ccdc22 gRNA vector 2 in pCas-Guide-CRISPRa

  GA205748G3, Ccdc22 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_138603
• Synonyms: AI481216; DXImx40e; Ppp1r3f; Sfc22
• Summary: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. [UniProtKB/Swiss-Prot Function]