Mouse Smad9 activation kit by CRISPRa

CAT#: GA205803

Smad9 CRISPRa kit - CRISPR gene activation of mouse SMAD family member 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Smad9
• Locus ID: 55994
• Kit Components:

  GA205803G1, Smad9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA205803G2, Smad9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA205803G3, Smad9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_019483
• Synonyms: MADH6; Madh8; Madh9; Smad8
• Summary: This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]