Mouse Akap8 activation kit by CRISPRa

CAT#: GA205946

Akap8 CRISPRa kit - CRISPR gene activation of mouse A kinase (PRKA) anchor protein 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Akap8
• Locus ID: 56399
• Kit Components:

  GA205946G1, Akap8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA205946G2, Akap8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA205946G3, Akap8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_019774, NR_131218, NR_131219, NM_001357760
• Synonyms: 1200016A02Rik; AA673585; AKAP-8; AKAP95; AU015639
• Summary: This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]