Mouse Sphk2 activation kit by CRISPRa

CAT#: GA206044

Sphk2 CRISPRa kit - CRISPR gene activation of mouse sphingosine kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Sphk2
• Locus ID: 56632
• Kit Components:

  GA206044G1, Sphk2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206044G2, Sphk2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206044G3, Sphk2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172561, NM_020011, NM_203280
• Synonyms: C76851
• Summary: This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]