Mouse Mmp19 activation kit by CRISPRa

CAT#: GA206273

Mmp19 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 19

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp19
• Locus ID: 58223
• Kit Components:

  GA206273G1, Mmp19 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206273G2, Mmp19 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206273G3, Mmp19 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164197, NM_021412
• Synonyms: MGC123370
• Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein develop a diet-induced obesity due to adipocyte hypertophy, exhibit decreased susceptibility to chemical carcinogen-induced skin tumors and early onset of tumoral angiogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]