Mouse F12 activation kit by CRISPRa

CAT#: GA206319

F12 CRISPRa kit - CRISPR gene activation of mouse coagulation factor XII (Hageman factor)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: F12
• Locus ID: 58992
• Kit Components:

  GA206319G1, F12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206319G2, F12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206319G3, F12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021489
• Synonyms: FXII; HAF
• Summary: This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]