Mouse Ncstn activation kit by CRISPRa

CAT#: GA206373

Ncstn CRISPRa kit - CRISPR gene activation of mouse nicastrin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ncstn
• Locus ID: 59287
• Kit Components:

  GA206373G1, Ncstn gRNA vector 1 in pCas-Guide-CRISPRa

  GA206373G2, Ncstn gRNA vector 2 in pCas-Guide-CRISPRa

  GA206373G3, Ncstn gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021607
• Synonyms: 9430068N19Rik; AA727311; Aph2; D1Dau13e; Kiaa0253; mKIAA0253; Nct
• Summary: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProtKB/Swiss-Prot Function]