Mouse Popdc2 activation kit by CRISPRa

CAT#: GA206433

Popdc2 CRISPRa kit - CRISPR gene activation of mouse popeye domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Popdc2
• Locus ID: 64082
• Kit Components:

  GA206433G1, Popdc2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA206433G2, Popdc2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA206433G3, Popdc2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081984, NM_022318
• Synonyms: AV006127; Pop2
• Summary: This gene encodes a member of the Popeye domain containing family of membrane proteins. Proteins of this family contain three helical transmembrane domains and a conserved intracellular Popeye domain. In the adult mouse, this gene is expressed at high levels in cardiac myocytes, and mice deficient for this gene develop stress-induced cardiac pacemaker dysfunction. The protein binds to a two-pore domain potassium channel and recruits it to the plasma membrane. Cyclic adenosine monophosphate negatively regulates this interaction through the Popeye domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]