Mouse Ears2 activation kit by CRISPRa

CAT#: GA207314

Ears2 CRISPRa kit - CRISPR gene activation of mouse glutamyl-tRNA synthetase 2, mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ears2
• Locus ID: 67417
• Kit Components:

  GA207314G1, Ears2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA207314G2, Ears2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA207314G3, Ears2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_026140
• Synonyms: 3230401I01Rik; mKIAA1970
• Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in a similar gene in human have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). [provided by RefSeq, Mar 2015]