Mouse Ucma activation kit by CRISPRa

CAT#: GA207846

Ucma CRISPRa kit - CRISPR gene activation of mouse upper zone of growth plate and cartilage matrix associated

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ucma
• Locus ID: 68527
• Kit Components:

  GA207846G1, Ucma gRNA vector 1 in pCas-Guide-CRISPRa

  GA207846G2, Ucma gRNA vector 2 in pCas-Guide-CRISPRa

  GA207846G3, Ucma gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001113558, NM_001165932, NM_001311208, NM_026754
• Synonyms: 1110017I16Rik; AW121955; Grp
• Summary: This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]