Mouse Srsf11 activation kit by CRISPRa

CAT#: GA208090

Srsf11 CRISPRa kit - CRISPR gene activation of mouse serine/arginine-rich splicing factor 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Srsf11
• Locus ID: 69207
• Kit Components:

  GA208090G1, Srsf11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA208090G2, Srsf11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA208090G3, Srsf11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001093752, NM_001093753, NM_026989, NM_001356997
• Synonyms: 0610009J05Rik; 2610019N13Rik; BF642805; Sfrs11
• Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]