Mouse March8 activation kit by CRISPRa

CAT#: GA208943

March8 CRISPRa kit - CRISPR gene activation of mouse membrane-associated ring finger (C3HC4) 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: March8
• Locus ID: 71779
• Kit Components:

  GA208943G1, March8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA208943G2, March8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA208943G3, March8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001302383, NM_001302384, NM_001302385, NM_027920
• Synonyms: 1300017E09Rik; MARCH-VIII; Mir
• Summary: The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]