Mouse Ndufv2 activation kit by CRISPRa
CAT#: GA209363
Ndufv2 CRISPRa kit - CRISPR gene activation of mouse NADH:ubiquinone oxidoreductase core subunit V2
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | Ndufv2 |
Locus ID | 72900 |
Kit Components | GA209363G1, Ndufv2 gRNA vector 1 in pCas-Guide-CRISPRa GA209363G2, Ndufv2 gRNA vector 2 in pCas-Guide-CRISPRa GA209363G3, Ndufv2 gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001278415, NM_028388 |
Synonyms | 2900010C23Rik |
Summary | This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN510863 | Ndufv2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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