Mouse Secisbp2 activation kit by CRISPRa

CAT#: GA210205

Secisbp2 CRISPRa kit - CRISPR gene activation of mouse SECIS binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Secisbp2
• Locus ID: 75420
• Kit Components:

  GA210205G1, Secisbp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA210205G2, Secisbp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA210205G3, Secisbp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308448, NM_029279
• Synonyms: 2210413N07Rik; 2810012K13Rik; SBP2
• Summary: The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in a similar gene in human have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2015]