Mouse Il33 activation kit by CRISPRa

CAT#: GA210715

Il33 CRISPRa kit - CRISPR gene activation of mouse interleukin 33

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il33
• Locus ID: 77125
• Kit Components:

  GA210715G1, Il33 gRNA vector 1 in pCas-Guide-CRISPRa

  GA210715G2, Il33 gRNA vector 2 in pCas-Guide-CRISPRa

  GA210715G3, Il33 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164724, NM_133775, NM_001360725
• Synonyms: 9230117N10Rik; Il-33; Il1f11; NF-HEV
• Summary: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. [UniProtKB/Swiss-Prot Function]