Mouse Dnajb1 activation kit by CRISPRa

CAT#: GA211184

Dnajb1 CRISPRa kit - CRISPR gene activation of mouse DnaJ heat shock protein family (Hsp40) member B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Dnajb1
• Locus ID: 81489
• Kit Components:

  GA211184G1, Dnajb1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA211184G2, Dnajb1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA211184G3, Dnajb1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308227, NM_018808
• Synonyms: 0610007I11Rik; DjB1; Hdj1; Hsp40; HSPF1
• Summary: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]