Mouse Ucn3 activation kit by CRISPRa

CAT#: GA211216

Ucn3 CRISPRa kit - CRISPR gene activation of mouse urocortin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ucn3
• Locus ID: 83428
• Kit Components:

  GA211216G1, Ucn3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA211216G2, Ucn3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA211216G3, Ucn3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_031250
• Synonyms: ucn III
• Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]