Mouse Clps activation kit by CRISPRa

CAT#: GA212254

Clps CRISPRa kit - CRISPR gene activation of mouse colipase, pancreatic

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Clps
• Locus ID: 109791
• Kit Components:

  GA212254G1, Clps gRNA vector 1 in pCas-Guide-CRISPRa

  GA212254G2, Clps gRNA vector 2 in pCas-Guide-CRISPRa

  GA212254G3, Clps gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317065, NM_025469
• Synonyms: 2200003J09Rik
• Summary: This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]