Mouse Pmch activation kit by CRISPRa

CAT#: GA212306

Pmch CRISPRa kit - CRISPR gene activation of mouse pro-melanin-concentrating hormone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pmch
• Locus ID: 110312
• Kit Components:

  GA212306G1, Pmch gRNA vector 1 in pCas-Guide-CRISPRa

  GA212306G2, Pmch gRNA vector 2 in pCas-Guide-CRISPRa

  GA212306G3, Pmch gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_029971
• Synonyms: A230109K23Rik
• Summary: This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]