Mouse Adarb1 activation kit by CRISPRa

CAT#: GA212323

Adarb1 CRISPRa kit - CRISPR gene activation of mouse adenosine deaminase, RNA-specific, B1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adarb1
• Locus ID: 110532
• Kit Components:

  GA212323G1, Adarb1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA212323G2, Adarb1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA212323G3, Adarb1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024837, NM_001024838, NM_001024839, NM_001024840, NM_130895, NR_004429, NR_021486
• Synonyms: 1700057H01Rik; Adar2; AW124433; AW558573; BB220382; D10Bwg0447e; Red1
• Summary: This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]