Mouse Scn2a activation kit by CRISPRa

CAT#: GA212362

Scn2a CRISPRa kit - CRISPR gene activation of mouse sodium channel, voltage-gated, type II, alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Scn2a
• Locus ID: 110876
• Kit Components:

  GA212362G1, Scn2a gRNA vector 1 in pCas-Guide-CRISPRa

  GA212362G2, Scn2a gRNA vector 2 in pCas-Guide-CRISPRa

  GA212362G3, Scn2a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001099298, NM_001346679, NM_001346680
• Synonyms: 6430408L10; A230052E19Rik; Nav1.2; Scn2a1
• Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]