Mouse Ucn2 activation kit by CRISPRa

CAT#: GA212676

Ucn2 CRISPRa kit - CRISPR gene activation of mouse urocortin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ucn2
• Locus ID: 171530
• Kit Components:

  GA212676G1, Ucn2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA212676G2, Ucn2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA212676G3, Ucn2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_145077
• Synonyms: Ucn-2; ucn-II; Ucn II
• Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit increased insulin sensitivity and were protected against fat-induced insulin resistance. In addition, female mice lacking the encoded protein exhibit a significant increase in the basal daily rhythms of adrenocorticotropic hormone and corticosterone, and a significant decrease in fluid intake and depressive-like behavior. [provided by RefSeq, Sep 2016]