Mouse Fgd4 activation kit by CRISPRa

CAT#: GA213660

Fgd4 CRISPRa kit - CRISPR gene activation of mouse FYVE, RhoGEF and PH domain containing 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fgd4
• Locus ID: 224014
• Kit Components:

  GA213660G1, Fgd4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA213660G2, Fgd4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA213660G3, Fgd4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301817, NM_001301818, NM_139232, NM_139233, NM_139234
• Synonyms: 9030023J02Rik; 9330209B17Rik; Frabp; ZFYVE6
• Summary: This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]