Mouse Zfp521 activation kit by CRISPRa

CAT#: GA213760

Zfp521 CRISPRa kit - CRISPR gene activation of mouse zinc finger protein 521

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Zfp521
• Locus ID: 225207
• Kit Components:

  GA213760G1, Zfp521 gRNA vector 1 in pCas-Guide-CRISPRa

  GA213760G2, Zfp521 gRNA vector 2 in pCas-Guide-CRISPRa

  GA213760G3, Zfp521 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_145492, NM_181326, NM_001360804
• Synonyms: B930086A16Rik; Evi3; Znf521
• Summary: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. [UniProtKB/Swiss-Prot Function]