Mouse Nppa activation kit by CRISPRa

CAT#: GA214217

Nppa CRISPRa kit - CRISPR gene activation of mouse natriuretic peptide type A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nppa
• Locus ID: 230899
• Kit Components:

  GA214217G1, Nppa gRNA vector 1 in pCas-Guide-CRISPRa

  GA214217G2, Nppa gRNA vector 2 in pCas-Guide-CRISPRa

  GA214217G3, Nppa gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008725
• Synonyms: Anf; ANP; Pnd
• Summary: This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]