Mouse Klk8 activation kit by CRISPRa

CAT#: GA215882

Klk8 CRISPRa kit - CRISPR gene activation of mouse kallikrein related-peptidase 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Klk8
• Locus ID: 259277
• Kit Components:

  GA215882G1, Klk8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA215882G2, Klk8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA215882G3, Klk8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001324398, NM_008940
• Synonyms: BSP1; NP; Nrpn; Prss19
• Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]