Mouse Klk14 activation kit by CRISPRa

CAT#: GA216201

Klk14 CRISPRa kit - CRISPR gene activation of mouse kallikrein related-peptidase 14

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Klk14
• Locus ID: 317653
• Kit Components:

  GA216201G1, Klk14 gRNA vector 1 in pCas-Guide-CRISPRa

  GA216201G2, Klk14 gRNA vector 2 in pCas-Guide-CRISPRa

  GA216201G3, Klk14 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_174866
• Synonyms: GK14
• Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The encoded protein is a precursor that undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. The encoded enzyme was found to activate the complement pathway by cleavage of C3 to release C3a anaphylotoxin. This gene is one of the several glandular kallikrein genes located in a cluster on chromosome 7. [provided by RefSeq, Aug 2015]