Mouse Fndc5 activation kit by CRISPRa

CAT#: GA217278

Fndc5 CRISPRa kit - CRISPR gene activation of mouse fibronectin type III domain containing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fndc5
• Locus ID: 384061
• Kit Components:

  GA217278G1, Fndc5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA217278G2, Fndc5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA217278G3, Fndc5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_027402
• Synonyms: 1500001L03Rik; AI836596; C87088; PeP; Pxp
• Summary: This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]