COX11 Human Gene Knockout Kit (CRISPR)
CAT#: KN203238BN
COX11 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | COX11 |
Locus ID | 1353 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001162861, NM_001162862, NM_001321518, NM_004375, NR_027941, NR_027942, NR_135677 |
Synonyms | COX11P |
Summary | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN203238 | COX11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN203238LP | COX11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN203238RB | COX11 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN403238 | COX11 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA100944 | COX11 CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase copper chaperone COX11 |
USD 1,290.00 |
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