TAZ (WWTR1) Human Gene Knockout Kit (CRISPR)
CAT#: KN204082BN
WWTR1 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | WWTR1 |
Locus ID | 25937 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001168278, NM_001168280, NM_015472, NM_001348362 |
Synonyms | TAZ |
Summary | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. [UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN204082 | WWTR1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN204082LP | WWTR1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN204082RB | WWTR1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN404082 | WWTR1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA108643 | WWTR1 CRISPRa kit - CRISPR gene activation of human WW domain containing transcription regulator 1 |
USD 1,290.00 |
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