Dopamine beta Hydroxylase (DBH) Human Gene Knockout Kit (CRISPR)
CAT#: KN212355
DBH - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control |
Donor DNA | GFP-puro |
Symbol | Dopamine beta Hydroxylase |
Locus ID | 1621 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000787 |
Synonyms | DBM |
Summary | 'The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN212355BN | DBH - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN212355LP | DBH - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN212355RB | DBH - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN412355 | DBH - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
|
GA101143 | DBH CRISPRa kit - CRISPR gene activation of human dopamine beta-hydroxylase |
USD 1,290.00 |
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