GPR56 (ADGRG1) Human Gene Knockout Kit (CRISPR)

CAT#: KN400315

ADGRG1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: ADGRG1
• Locus ID: 9289
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001145770, NM_001145771, NM_001145772, NM_001145773, NM_001145774, NM_001290142, NM_001290143, NM_001290144, NM_005682, NM_201524, NM_201525, NM_001370428, NM_001370429, NM_001370430, NM_001370432, NM_001370433, NM_001370434, NM_001370436, NM_001370439, NM_001370440, NM_001370451, NM_001370431, NM_001370435, NM_001370437, NM_001370438, NM_001370441, NM_001370442, NM_001370453, NM_001370454
• Synonyms: BFPP; BPPR; GPR56; TM7LN4; TM7XN1
• Summary: This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]