APEX2 Human Gene Knockout Kit (CRISPR)
CAT#: KN400320
APEX2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | APEX2 |
Locus ID | 27301 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001271748, NM_014481 |
Synonyms | APE2; APEXL2; XTH2; ZGRF2 |
Summary | Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] |
Documents
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FAQs |
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN200320 | APEX2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN200320BN | APEX2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN200320LP | APEX2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN200320RB | APEX2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
GA109110 | APEX2 CRISPRa kit - CRISPR gene activation of human apurinic/apyrimidinic endodeoxyribonuclease 2 |
USD 1,290.00 |
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