Superoxide Dismutase 1 (SOD1) Human Gene Knockout Kit (CRISPR)
CAT#: KN400725
SOD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | Superoxide Dismutase 1 |
Locus ID | 6647 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_000454 |
Synonyms | ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD |
Summary | 'The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]' |
Documents
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Other Versions
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KN200725 | SOD1 - human gene knockout kit via CRISPR, HDR mediated |
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KN200725BN | SOD1 - human gene knockout kit via CRISPR, HDR mediated |
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KN200725LP | SOD1 - human gene knockout kit via CRISPR, HDR mediated |
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KN200725RB | SOD1 - human gene knockout kit via CRISPR, HDR mediated |
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