ABCD4 Human Gene Knockout Kit (CRISPR)

CAT#: KN401291

ABCD4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: ABCD4
• Locus ID: 5826
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_005050, NM_020323, NM_020324, NM_020325, NM_020326, NR_003256, NM_001353591, NM_001353592, NM_001353593, NM_001353594, NM_001353595, NM_001353596, NM_001353597, NM_001353598, NM_001353599, NM_001353600, NM_001353601, NM_001353602, NM_001353603, NM_001353604, NM_001353605, NM_001353606, NM_001353607, NM_001353608, NM_001353609, NM_001353610, NR_148466, NR_148467, NR_148468, NR_148469, NR_148470, NR_148471, NR_148472, NR_148473, NR_148474
• Synonyms: ABC41; EST352188; MAHCJ; P70R; P79R; PMP69; PXMP1L
• Summary: 'The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]'