CCM2 Human Gene Knockout Kit (CRISPR)
CAT#: KN401418
CCM2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
KN401418 is the updated version of KN201418.
USD 1,290.00
2 Weeks*
Size
Other products for "CCM2"
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | CCM2 |
Locus ID | 83605 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001029835, NM_001167934, NM_001167935, NM_031443, NR_030770, NM_001363458, NM_001363459 |
Synonyms | C7orf22; OSM; PP10187 |
Summary | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
GA113212 | CCM2 CRISPRa kit - CRISPR gene activation of human CCM2 scaffold protein |
USD 1,290.00 |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.