Human CCM2 activation kit by CRISPRa

CAT#: GA113212

CCM2 CRISPRa kit - CRISPR gene activation of human CCM2 scaffold protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCM2
• Locus ID: 83605
• Kit Components:

  GA113212G1, CCM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113212G2, CCM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113212G3, CCM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001029835, NM_001167934, NM_001167935, NM_031443, NR_030770, NM_001363458, NM_001363459
• Synonyms: C7orf22; OSM; PP10187
• Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]