ASCC1 Human Gene Knockout Kit (CRISPR)

CAT#: KN401872

ASCC1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: ASCC1
• Locus ID: 51008
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001198798, NM_001198799, NM_001198800, NM_015947, NR_045564, NM_001369086, NM_001369085, NM_001369087, NM_001369088, NM_001369090, NM_001369091, NM_001369095, NM_001369098, NM_001369099, NM_001369102, NM_001369107, NM_001369110, NM_001369111, NM_001369112, NM_001369089, NM_001369092, NM_001369093, NM_001369094, NM_001369096, NM_001369097, NM_001369100, NM_001369101, NM_001369103, NM_001369104, NM_001369105, NM_001369106, NM_001369108, NM_001369109
• Synonyms: ASC1p50; CGI-18; p50
• Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]