Calpastatin (CAST) Human Gene Knockout Kit (CRISPR)

CAT#: KN402168

CAST - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: Calpastatin
• Locus ID: 831
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001042440, NM_001042441, NM_001042442, NM_001042443, NM_001042444, NM_001042445, NM_001042446, NM_001190442, NM_001284212, NM_001284213, NM_001330626, NM_001330627, NM_001330628, NM_001330629, NM_001330630, NM_001330631, NM_001330632, NM_001330633, NM_001330634, NM_001750, NM_173060, NM_173061, NM_173062, NM_173063, NR_033798, NR_104285
• Synonyms: BS-17; PLACK
• Summary: 'The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]'