PIAS2 Human Gene Knockout Kit (CRISPR)

CAT#: KN403294

PIAS2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: PIAS2
• Locus ID: 9063
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_004671, NM_173206, NM_001324046, NM_001324047, NM_001324048, NM_001324049, NM_001324051, NM_001324052, NM_001324053, NM_001324054, NM_001324055, NM_001324057, NM_001324058, NM_001324059, NM_001324060, NM_001354033, NM_001354034, NM_001354035, NM_001354036, NM_001354037, NM_001354038, NM_001354039, NR_136684, NR_136685, NR_148699, NR_148700, NR_148701, NR_148702, NR_148703
• Synonyms: ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
• Summary: This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]