FBXL2 Human Gene Knockout Kit (CRISPR)

CAT#: KN406390

FBXL2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: FBXL2
• Locus ID: 25827
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001171713, NM_012157, NM_001349316, NM_001349319, NM_001349320, NM_001349321, NM_001349322, NM_001349323, NM_001349324, NM_001349325, NM_001349326, NR_146121, NR_146122, NR_146123, NR_146124, NR_146125, NR_146126, NR_146127, NR_146128, NR_146129, NR_146130, NR_146131, NR_146132, NR_146133, NR_146134, NR_146135
• Synonyms: FBL2; FBL3
• Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]