MMP19 Human Gene Knockout Kit (CRISPR)

CAT#: KN408245

MMP19 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: MMP19
• Locus ID: 4327
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001032360, NM_001272101, NM_002429, NM_022790, NM_022791, NM_022792, NR_073606
• Synonyms: matrix metallopeptidase 19; matrix metalloproteinase 18; matrix metalloproteinase 19; MMP18; MMP18, RASI-1; RASI-1
• Summary: 'This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]'