MTRR Human Gene Knockout Kit (CRISPR)

CAT#: KN408784

MTRR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: MTRR
• Locus ID: 4552
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_002454, NM_024010, NR_134480, NR_134481, NR_134482, NM_001364440, NM_001364442, NR_157168, NR_157172, NR_157175, NR_157176, NR_157177, NR_157178, NM_001364441, NR_157169, NR_157170, NR_157171, NR_157173, NR_157174
• Synonyms: cblE; MSR
• Summary: 'This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]'