Human MTRR activation kit by CRISPRa

CAT#: GA103030

MTRR CRISPRa kit - CRISPR gene activation of human 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTRR
• Locus ID: 4552
• Kit Components:

  GA103030G1, MTRR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103030G2, MTRR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103030G3, MTRR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002454, NM_024010, NR_134480, NR_134481, NR_134482, NM_001364440, NM_001364442, NR_157168, NR_157172, NR_157175, NR_157176, NR_157177, NR_157178, NM_001364441, NR_157169, NR_157170, NR_157171, NR_157173, NR_157174
• Synonyms: cblE; MSR
• Summary: 'This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]'