DAB1 Human Gene Knockout Kit (CRISPR)

CAT#: KN414664

DAB1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: DAB1
• Locus ID: 1600
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_021080, NM_001353980, NM_001353983, NM_001353985, NM_001353986, NM_001365792, NM_001365793, NM_001365794, NM_001365795
• Synonyms: disabled homolog 1; disabled homolog 1 (Drosophila); OTTHUMP00000010045; OTTHUMP00000011753
• Summary: 'The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]'