CARD15 (NOD2) Human Gene Knockout Kit (CRISPR)
CAT#: KN415750
NOD2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | NOD2 |
Locus ID | 64127 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001293557, NM_022162, NM_001370466, NR_163434 |
Synonyms | ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 |
Summary | This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN215750 | NOD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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KN215750BN | NOD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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KN215750LP | NOD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN215750RB | NOD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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GA111990 | NOD2 CRISPRa kit - CRISPR gene activation of human nucleotide binding oligomerization domain containing 2 |
USD 1,290.00 |
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