SETD2 Human Gene Knockout Kit (CRISPR)
CAT#: KN424760
SETD2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | HYPB |
Locus ID | 29072 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_012271, NM_014159, NM_001349370, NR_146158 |
Synonyms | FLJ16420; FLJ22472; FLJ45883; HIF1; KIAA1732 |
Summary | Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
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KN224760 | SETD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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KN224760BN | SETD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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KN224760LP | SETD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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KN224760RB | SETD2 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
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GA109212 | SETD2 CRISPRa kit - CRISPR gene activation of human SET domain containing 2, histone lysine methyltransferase |
USD 1,290.00 |
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