Human SETD2 activation kit by CRISPRa

CAT#: GA109212

SETD2 CRISPRa kit - CRISPR gene activation of human SET domain containing 2, histone lysine methyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SETD2
• Locus ID: 29072
• Kit Components:

  GA109212G1, SETD2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109212G2, SETD2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109212G3, SETD2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012271, NM_014159, NM_001349370, NR_146158
• Synonyms: FLJ16420; FLJ22472; FLJ45883; HIF1; KIAA1732
• Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]