Ctsb Mouse Gene Knockout Kit (CRISPR)
CAT#: KN503984
Ctsb - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | Ctsb |
Locus ID | 13030 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_007798 |
Synonyms | CB |
Summary | This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN303984 | Ctsb - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN303984BN | Ctsb - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN303984LP | Ctsb - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN303984RB | Ctsb - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
GA200946 | Ctsb CRISPRa kit - CRISPR gene activation of mouse cathepsin B |
USD 1,290.00 |
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